Atoris is registered as a product of the Slovenian pharmacological company KRKA. This is a high-quality and affordable generic of Atorvastatin, which was previously sold only as Pfizer's Liprimar drug. At the moment, its analogues ("Atoris", "Torvacard" and others) have firmly entered clinical practice and are high-quality hypocholesterolemic drugs.

Release form

The drug "Atoris" is available in tablets of three standard dosages. These are 10, 20 and 40 mg. Sold in cardboard packaging, with tablets placed in blisters. Carton pack capacity: 10, 30 and 90 Atoris tablets (instructions for use). Analogues of the drug and generics may contain an identical amount of the active substance, but not have the same effect due to differences in the components.

The composition of the drug "Atoris"

The active ingredient is atorvastatin, a third-generation statin. Auxiliary substances are the following: polyvinyl alcohol, macrogol 3000, talc, croscarmellose sodium, microcrystalline cellulose, lactose monohydrate, povidone, calcium carbonate, sodium lauryl sulfate.

Excipients determine the tablet dosage form and determine the rate of absorption of atorvastatin into the blood. Accordingly, any analogue of the drug "Atoris" should contain the same amount of active substance and be released at the same rate, creating similar concentrations in the blood.

Rationale for the use of statins and Atoris

The drug "Atoris" contains atorvastatin as an active ingredient. It belongs to the category of substances of the third generation. A lot of studies have been conducted with him, confirming the feasibility of taking it in the presence of risk factors for atherosclerosis or with an already developed disease. "Atorvastatin", its analogues, "Atoris" and other statins significantly reduce the ability of low-density lipoprotein (LDL) to cause atherosclerosis and lead to its aggravation. This is their clinical value, because with their direct participation, the frequency of developing heart attacks decreases.

Pharmacological effects

The most important consequence of taking it is the inhibition of cholesterol synthesis through inhibition of the enzyme HMG-CoA reductase. The result is a cessation or a significant decrease in the synthesis of LDL. This fraction of lipoproteins provokes atherosclerosis, causes narrowing of the wall and its thickening in the arteries of the heart, brain and lower extremities. Along with a decrease in the amount of LDL, the concentration increases

They perform important work: increasing the resistance of membranes to mechanical and chemical influences by incorporating cholesterol into it. Thus, HDL utilizes but does not accumulate cholesterol. LDL leads to its accumulation behind the vascular endothelium, provoking atherosclerosis, while high-density lipoprotein reduces the rate of cholesterol deposition, but does not remove it from under the inner lining of the elastic-type artery.

Method of application of the drug "Atoris"

Recommendations on how to take Atoris boil down to clarifying some aspects. In particular, the medicine is taken in the prescribed dose once a day after dinner before going to bed. A single dose can be 10, 20 and 40 mg. Since the drug is a prescription drug, a doctor's consultation is required to purchase it. It is he who, after analyzing the lipidogram fractions and assessing the level of total blood cholesterol, is able to recommend the correct dosage of atorvastatin, its class analogues or generics.

With an initial cholesterol level of 7.5 and above, it is recommended to take 80 mg / day. A similar dosage is prescribed to patients who have suffered or are in the acute period of its course. At a concentration of 6.5 to 7.5, the recommended dose is 40 mg. 20 mg is taken at a cholesterol level of 5.5 - 6.5 mmol / liter. 10 mg of the drug is recommended for children from 10 to 17 years of age with heterozygous hypercholesterolemia, as well as adults with primary hypercholesterolemia.

Requirements for generics

A qualitative analogue of the drug "Atoris" should contain an identical amount of the active substance and create similar concentrations in the blood. Provided that the product is such, it is recognized as bioequivalent and capable of completely replacing the original. In relation to the drug "Liprimar", the analogue is "Atoris", created on the basis of atorvastatin.

Requirements for clinical analogues of "Atoris"

Any substitute for "Atoris", its class or analogue in composition, must contain any of the statins. It is in this case that it can be used as a full-fledged equivalent. Moreover, the replacement of the drug "Atoris" with an analogue should be carried out while maintaining the prescribed dosage. If 10 mg of Atoris is used, then the other drug should also show a similar or greater activity.

Generics "Liprimara"

Since Liprimar is the original atorvastatin, all drugs with the same active ingredient should be compared with it. Analogues, among which Atoris is the most balanced in terms of price, should also be considered from this point of view. So, there are similar medicines with a higher cost, with an equivalent and with a lower one. Full analogues of "Atoris":

• expensive ("Liprimar");
• equally accessible ("Torvacard", "Tulip");
• cheaper ones (Lipromak, Atomax, Lipoford, Liptonorm).

As can be seen, atorvastatin analogues are widely represented. Even more of them are offered in a low price category. Here you should indicate the mass of drugs with the trade name "Atorvastatin", which are produced under the license of large pharmacological companies.

If you look for an analogue of Atoris, any domestically produced atorvastatin under license will be cheaper. The highest quality and fully consistent with the described is "Atorvastatin" of the Borisov Pharmaceutical Plant, located in Belarus. Here, the production of the drug is controlled by the KRKA company, which produces Atoris.

Features of drug replacement

In the question of how to replace Atoris, it is important to consider several conditions. First, the drug must have appropriate clinical efficacy and be well tolerated. Secondly, its price should be lower, or, if the drug belongs to class analogues, slightly higher. Thirdly, the previous dose must be observed if the replacement is made for a generic. In the case of switching to a class analogue of the drug, it is important to receive an equivalent dose.

Replacement with generics

Among the drugs containing atorvastatin, the following are of the highest quality: Liprimar, Torvacard, Lipromak and Atoris. Analogues, reviews of which are few, are inferior to them in terms of efficiency and safety. Although they are the best for the price. They can be recommended to patients who do not care about the bioequivalence of the generic or do not want to overpay. There is no apparent difference in the effects of this, although the quality of treatment suffers to some extent.

If we consider generic atorvastatin, it is recommended to choose from among those indicated above. But, for example, deciding what to choose - "Atoris" or "Torvacard" is not easy. The reason for this is the almost complete compliance of these drugs in terms of price and effectiveness. Moreover, their price is often also similar. Above them in quality is "Liprimar", and below - "Lipromak". At the same time, the latter, with a slight difference in ingredients, is more affordable.

Replacement with Atoris class counterparts

The drug "Atoris" analogues in Ukraine and other CIS countries are class. That is, the drug contains another statin, respectively, with other characteristics. It is most reasonable to change "Atoris" to "Pitavastatin" or "Rozuvastatin" with a slight degree of reduction in LDL. Moreover, the latter are safer and have a therapeutic effect at a lower dose.

There are also early analogues: Atoris looks more preferable than them, although they have the full clinical effect. For example, Simvastatin is the most affordable drug with proven safety in clinical trials. The original original is "Zokor". If we consider affordable and high-quality as a replacement for Atoris, then it is better to take Mertenil as an example. This is no less studied Rosuvastatin, a generic with an affordable price.